Reduced uterine perfusion pressure causes loss of pancreatic β-cell area but normal function in fetal rat offspring
نویسندگان
چکیده
منابع مشابه
Rat maternal diabetes impairs pancreatic -cell function in the offspring
Han J, Xu J, Long YS, Epstein PN, Liu YQ. Rat maternal diabetes impairs pancreatic -cell function in the offspring. Am J Physiol Endocrinol Metab 293: E228–E236, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00479.2006.—It has been shown that maternal diabetes increases the risk for obesity, glucose intolerance, and Type 2 diabetes mellitus in the adult life of the offspring. Mechan...
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متن کاملHigh-salt diet enhances vascular reactivity in pregnant rats with normal and reduced uterine perfusion pressure.
High-salt (HS) diet is often associated with increased vascular resistance and arterial pressure; however, the effects of HS intake on the vascular control mechanisms of arterial pressure during pregnancy are unclear. We investigated whether a HS diet during pregnancy is associated with increases in vascular reactivity. Active stress was measured in aortic strips of virgin and normal pregnant S...
متن کاملReduced uterine perfusion pressure induces hypertension in the pregnant mouse.
Despite preeclampsia being one of the leading causes of maternal death and a major contributor of maternal and perinatal morbidity, the mechanisms responsible for its pathogenesis have yet to be fully elucidated. Growing evidence indicates that reduced uteroplacental perfusion and the resulting placental ischemia triggers the cascade of events leading to this maternal disorder. While the well-e...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2018
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00458.2017